Mr Peter Constable
Consultant Ophthalmologist, Specialist Cataract and Glaucoma Surgeon
BM, BCh, MA, MD, FRCOphth
After studying medicine at Cambridge and Oxford universities, I completed my higher specialist training at Moorfields Eye Hospital, London, gaining comprehensive clinical and surgical experience in all of the major specialities within ophthalmology. I spent two years as a Research Fellow in the Institute of Ophthalmology, researching into treatments that regulate how eyes heal after surgery, gaining my doctorate in 1998. In addition I completed a clinical Fellowship in the Glaucoma Unit at Moorfields, gaining extensive experience into all aspects of the surgical and medical management of glaucoma. I have had a broad surgical training, including the use of modern small incision phacoemulsification and refractive surgery techniques to give improved outcomes after cataract surgery.
In my consultant post, I provide a broad general ophthalmic service at the Royal Berkshire Hospital in Reading, running specialist glaucoma and cataract services, as well as running specialist clinics for medical retina problems and glaucoma, and a specialist cataract service. I am also establishing an active glaucoma research programme in the eye unit at the Royal Berkshire Hospital.
During my training and research I have been awarded many prizes including: Open Exhibition to Fitzwilliam College, Cambridge; Samuel Edwards Exhibition to Stamford School; Reddaway Prize, Fitzwilliam College Cambridge; I.C.I. Pathology Bursary; T.F.C.Frost Fellowship to Glaucoma Unit, Moorfields Eye Hospital and Institute of Ophthalmology; Ian Fraser Prize, Oxford Congress 1996.
Some of the principal treatments carried out by Mr Peter Constable at Spire include:
BM BCh / Oxford / 1988
Bachelor of Medicine
MA / Cambridge University / 1985
Master of Arts
I worked for two years as a fellow in the Glaucoma Unit at Moorfields Eye Hospital, during which time I successfully completed a period of research into the effects of focal beta radiation on ocular fibroblast wound healing functions. This work formed part of the ongoing international wound healing project, which is a collaborative study between Professor Peng T Khaw at the Institute of Ophthalmology, the Phoenix plastic surgery unit at University College London and the University of Florida. The underlying basis for the work was the current interest in treatments which may be effective in modulating the scarring response which occurs after glaucoma filtration surgery, as this may significantly improve the outcome after drainage surgery and reduce the chance of patients suffering progressive visual field loss.
During this research period I was principally engaged in laboratory based studies into the effects of beta radiation on ocular fibroblast wound healing functions, but in addition I maintained a close clinical commitment within the Glaucoma unit, with weekly special clinics in paediatric glaucoma, normal pressure glaucoma as well as general adult glaucoma and tertiary referrals with complex glaucoma problems. I also was closely involved in the weekly teaching programme within the unit, which was actively engaged in several exciting areas of glaucoma research including analysis of visual field progression, new psychophysical tests for glaucoma, optic disc analysis techniques and glaucoma epidemiology.
The research work for my thesis involved both in-vitro human cell culture experimentation and in-vivo animal work, using a new model of conjunctival healing that we developed using the New Zealand albino rabbit. I developed and used experimental assays to investigate the effects of radiation on cell proliferation and cell cycling, and the subcellular cellular mechanisms controlling this response. In addition I also studied the effects of radiation on cell contraction, migration and extracellular matrix production. In addition to this work, I was also closely involved in studies using other anti-metabolite agents such as 5-Fluorouracil and Mitomycin C and their cellular effects such as apoptosis, as well as the role of growth factors such as TGF-b. This period of research has provided extensive knowledge into much of the current research in glaucoma, as well as a detailed knowledge of cell biology research techniques and experimental design.
My MD thesis was submitted to the University of Cambridge in May 1998, and awarded in October 1998.
Use of Topical Diclofenac in Association with External Ocular Compression. P.H.Constable, G.G.W.Adams. EYE 1994 vol. 8 (4) : 462 -464.
Bilateral angle closure glaucoma and accelerated cataract formation in a patient with AIDS. Joshi, N, Constable,PH, Margolis,TP, Hoyt,CS , Leonard,TJ.. British Journal of Ophthalmology (1994). 78(8) 656-657
Early growth arrest of human Tenon’s capsule fibroblasts following single doses of beta radiation. P.H.Constable, N.L.Occleston, M.F.Cordeiro, C.H.Kon and P.T.Khaw Invest.Ophthalmol. Vis Sci (37) : 3-S24 (1996)
Induction of apoptosis in Tenon’s capsule fibroblasts with Mitomycin C and 5 Fluorouracil J.G.Crowston, P.H.Constable, N.L.Occleston, H.Hyde, A.N.Akbar and P.T.Khaw Invest.Ophthalmol. Vis Sci (37) : 3-S1118 (1996)
Preventing scarring after glaucoma filtration surgery with single application agents: A practical approach. Khaw, P.T., Tsai, J, Constable,PH, Cordeiro,MF,, Occleston,N.L. Asia-Pac J.Ophthalmol 6(5):35-42 (1995)
Effect of TGF-beta 1,2 and 3 on human ocular fibroblast populated collagen lattice contraction. Cordeiro, M.F., Occleston, N.L., Constable,PH, Bhattacharya,SS, Khaw,PT. Vision Research 35: S81 (1995)
The effect of single doses of beta radiation on bleb survival and morphology in a rabbit model of filtration surgery. P.H.Constable, M.F.Cordeiro , J.G.Crowston and P.T.Khaw Invest.Ophthalmol. Vis Sci (39) : 3-S1110 (1998)
Long term growth arrest of human Tenon's capsule fibroblasts following single applications of beta radiation. Constable PH, Crowston JG, Occleston NL, Cordeiro MF, Khaw PT Br J Ophthalmol 1998;82:448-452
Effect of varying the Mitomycin-C treatment area in glaucoma filtration surgery in the rabbit. Cordeiro MF, Constable PH, Alexander RA, Bhattacharya SS, Khaw PT Invest Ophthalmol Vis Sci 1997;38(8):1639-1646
Royal Berkshire Hospital Reading and Newbury Hospital