Peyronie’s Disease

30 July 2018

What is Peyronie’s Disease?

In the male population, Peyronie’s Disease (PD) is one of the most frequently under-reported diseases. It results in penile pain and curvature during erections, affecting individual’s physiological and psychological well-being, due to the impact it has upon individual’s sex lives.

Although the exact underlying cause of PD is unknown, it can be associated with conditions such as Diabetes Mellitus, Hypertension and lipid abnormalities.

What are the treatment options?

Non-surgical option

This treatment involves injecting an enzyme within the PD plaque, resulting in softening and subsequently a reduction in the degree of the curvature. The injection is used in conjunction with penile remodelling, which is performed by the patient at least 3-4 times per day, which is vital for the success of the treatment. This form of treatment has several advantages:

  • Proven to improve individuals psychological well-being as well as the disease
  • Office-based procedure
  • Performed under local anaesthesia
  • Minimal side effects
  • Short recovery period

Surgical options:

  • Corporal Plication (Nesbit procedure)
    Stitches are applied on the layer opposite the plague in an attempt to restore the straight appearance of the erect penis. However, this procedure is associated with a decrease in penile length (by about two centimetres).
  • Plaque excision and grafting (Leu procedure)
    A more technically demanding procedure involving the removal of the plaque which theoretically means no loss of penile length. However, there are cases of these patients developing erectile dysfunction as a result.
  • Insertion of penile prosthesis
    This procedure is only carried out on patients who have tried the traditional methods such as tablets or injections, but still suffer with severe erectile dysfunction.


Written by Mr Aza Mohammed, Consultant Urological Surgeon

If you have any concerns, or wish to see Mr Mohammed or any of our other consultants,  please give us a call on 01582 714 420 to discuss your options.

1. Gelbard MK, James K, Riach P, Dorey F. Collagenase versus placebo in the treatment of Peyronie's disease: a double-blind study. J Urol. 1993 Jan;149(1):56-8. PubMed PMID: 8417217.

2. Hatzimouratidis K, Giuliano F, Moncada I, Muneer A, Salonia A, Verze P. European Urology Guidelines on male sexual dysfunction.

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