T-cell population differs in obese patients

10 March 2015

A new study has suggested that people who are obese or who have type 2 diabetes experience changes in their T-cell population.

In significantly overweight individuals or those who have obesity-induced type 2 diabetes, there is an accumulation of immune cells within adipose tissue, which results in lower levels of chronic inflammation, according to the research.

Published in the Journal of Clinical Investigation, the study found that the gut microbial populations also differ in these people, but weight loss through diet or weight loss surgery can improve type 2-associated symptoms and shifts the gut microbiota. 

According to the findings, a population of T-cells - called mucosal-associated invariant T (MAIT) cells - is different in patients with type 2 diabetes or who are severely obese. MAIT cells are responsible for recognising bacterial ligands in mucosal and inflamed tissues. 

The team compared participants with the condition or who were severely obese to a group of healthy controls and found that circulating MAIT cell population was dramatically reduced.  

For obese patients, it found that bariatric surgery-induced weight loss was able to restore circulating MAIT cells, while also reducing inflammatory cytokine production in these cells. cytokine production in these cells. 

Posted by Edward Bartel

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

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