New genetic marker could predict kidney transplant success

2 December 2014

A new study has identified a new genetic difference that could make kidney failure more likely after transplant. The research, published in the Journal of Clinical Investigation, found that a small change in the genetic coding of a kidney donor could make the organ more likely to suffer scarring once in the recipient.

The team at Icahn School of Medicine at Mount Sinai suggested that, if proven, this link could enable clinicians to better screen donors and eventually reduce the number of people suffering transplant rejection.

As well as this, the study could also help researchers develop drugs to target the mechanisms that trigger scarring in the kidney. It could also lead to improved treatment for patients diagnosed with chronic kidney disease, which can lead to renal failure and is worsened by fibrosis.

Chair of the Department of Medicine and professor of medicine at the Icahn School of Medicine at Mount Sinai Dr Barbara Murphy said it is "critically important" for new targets to be identified to stop scarring in transplanted kidneys. 

The research has linked a genetic marker, related protein pathways and poor outcomes after a kidney transplant, which could be targeted in the future, she added. 

Posted by Edward Bartel


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