Poor kidney function ‘linked to risk of renal and urothelial cancer’

30 May 2014

The glomerular filtration rate - a key measure of reduced kidney function and chronic kidney disease - is an independent risk factor for renal and urothelial cancer, according to research published in the Journal of the American Society of Nephrology.

To conduct the study, scientists analysed the records of almost 1.2 million adults aged 40 or over with known kidney function and no history of cancer, dialysis or renal transplantation. 

Patients with lower glomerular filtration rates tended to be older, be of an ethnic minority, be current or former smokers, have lower socioeconomic status and have other chronic diseases.

Glomerular filtration rates calculate how well kidneys are filtering blood, with the normal range falling between 60 and 89. A rate of 45 to 59 indicates moderate kidney disease and less than 30 suggests the condition has become severe chronic.

The results indicated a 39 per cent increased risk of renal cancer when patients' rate was 45 to 59 and a 100 per cent rise if it was less than 30. The risk of urothelial cancer increased by 48 per cent in participants with a rate of less than 30.

Juan Ordonez, co-author of the study, said: "These findings could have clinical implications for directing cancer-screening efforts in select populations,"

"Currently, there are no evidence-based cancer screening recommendations tailored for patients with chronic kidney disease."

Posted by Jeanette Royston


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