Ageing-related cells linked to osteoarthritis

12 August 2016

A new study has demonstrated a link between certain cells that accumulate with age and the onset of osteoarthritis.

The Mayo Clinic research indicated that there may be a causal link between senescent cells - which are linked to the ageing process and contribute to frailty and disease - and osteoarthritis in mice.

A small numbers of senescent and non-senescent cells from ear cartilage were injected into the knee joint area of mice. After tracking the mice for more than ten days, the senescent cells were linked to the development of leg pain, impaired mobility and characteristics of osteoarthritis.

Symptoms included damage to the surrounding cartilage, X-ray changes, increased pain and impaired function. This provides strong evidence that these cells may have a role to play in the development of the most common form of osteoarthritis.

Dr James Kirkland, director of the Robert and Arlene Kogod Center on Aging, said: "We believe that targeting senescent cells could be a promising way to prevent or alleviate age-related osteoarthritis. While there is more work to be done, these findings are a critical step toward that goal."

Posted by Edward Bartel

 


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