Frontline immune cells can travel for help

16 May 2015

A new study, published in Nature Communications journal, shows that the cells that form the majority of the fast-acting 'innate' immune system can behave differently. The research, conducted at the Garvan Institute of Medical Research in Sydney, found cells react differently when an injury becomes infected.

These 'neutrophils' swarm to injury sites within minutes of it happening but self-destruct once their job is completed. The team have now demonstrated that some neutrophils can also gather reinforcements to fight against pathogens if the injury is infected.

The extra cells come from the slower-acting 'adaptive' immune system by travelling to the nearest lymph node, which helps prepare other types of immune cell for attack.

Dr Tatyana Chtanova, from the Garvan Institute of Medical Research and project leader, said this is the first time that it has been shown what neutrophils actually do.

She said: "Neutrophils together with T cells will try to clean up infection everywhere, including in the lymph node. Microbes from infection sites can migrate to the lymph node in the lymph stream, separately from neutrophils, so T cell recruitment by neutrophils may help prevent microbial spread."

Posted by Edward Bartel

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Healthcare

© Spire Healthcare Group plc (2016)