Stem cell transplant without pre-treatment shows promise

10 December 2014

A new study has found that stem cell transplants can be a viable treatment solution even without pre-treatment courses of chemotherapy or radiotherapy.

This is according to data from a new clinical trial studying patients with a rare form of bone marrow failure who received a hematopoietic stem cell transplant (HSCT) after pre-treatment with immunosuppressive drugs only. 

The team from Dana-Farber/Boston Children's Cancer and Blood Disorders Center have presented the first data showing a successful transplant in dyskeratosis congenita (DC) patients without the use of any radiation or conventional cytotoxic chemotherapy beforehand.

Delivered by study authors Dr Leslie Lehmann and Dr Suneet Agarwal of Dana-Farber/Boston Children's at the 56th annual meeting of the American Society of Hematology, these findings suggest that this immunosuppression-only approach could benefit patients with DC. It could also help those with other bone marrow failure syndromes who are also at a high risk of poor transplant outcomes because they cannot tolerate the toxicity. 

"This experience begs the question of whether we can think more broadly about this approach's applicability for other conditions, something I think is worth considering," Dr Agarwal said.

Posted by ​Jeanette Royston​

 

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

 

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

General Surgery

© Spire Healthcare Group plc (2016)