Understanding fertility proteins could boost IVF success

20 March 2015

Women who struggle with fertility can turn to in-vitro fertilization (IVF) but this doesn't guarantee success. A team of researchers have now developed a new approach that could improve the accuracy of the current technique.

They studied the proteins that could help prepare a uterus to enable an embryo to implant in its wall. Their report, published in the American Chemical Society's (ACS) Journal of Proteome Research, could help develop a new IVF method with a higher success rate.

On average, IVF is only successful around a third of the time, with the majority of attempts failing because the embryo doesn't attach to the uterine wall. 

To better understand why this happens, the team looked at the proteins that could play a role in this process. They tested samples of the inner uterine membrane or endometrium from 12 women and found more than 2,000 proteins. In these proteins, the levels of more than 300 varied significantly depending on whether the endometrium was ready for embryo implantation. 

Changing these levels could increase a person's chances of implanting an embryo and increase the IVF success rate

Posted by Edward Bartel

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