Overeating 'negatively affects the ability of brain insulin'

18 October 2012

People who choose to overeat on a regular basis could see a malfunction in brain insulin signalling, new research has highlighted.

A study led by Christoph Buettner, associate professor of medicine at the Mount Sinai School of Medicine, also shed light on how this malfunctioning can result in a person become obese or suffering from diabetes.

The researchers underlined in their analysis that this occurs as overeating can impair the brain insulin's ability to suppress the breakdown of fat in adipose tissue.

In order to reach such conclusions, the scientists gave laboratory rats a high-fat diet that was comprised of ten per cent lard for three consecutive days.

This eating strategy not only increased the rats' daily caloric intake by up to 50 per cent, but also affected the brain insulin's ability to suppress glucose release from the liver and lipolysis in fat tissue.

Dr Buettner commented: "When you overeat, your brain becomes unresponsive to these important clues such as insulin, which puts you on the road to diabetes. We believe that what happens in rats also happens in humans."

Posted by Jeanette Royston

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