Genetic risk linked to statin therapy outcome

4 March 2015

A new study has highlighted that a number of genetic and lifestyle factors can impact a person's risk of developing coronary heart disease.

Researchers from Brigham and Women's Hospital (BWH), Washington University School of Medicine in St Louis, and Massachusetts General Hospital (MGH) examined a number of genetic variants that could help determine cardiac risk.

The team found that a genetic risk score could identify individuals who did or did not have coronary disease and were at an increased risk of suffering cardiovascular death or a heart attack.

Individuals in the highest genetic risk score group had a 70 per cent increased risk of suffering cardiovascular death or a heart attack, compared to the lowest risk group. 

The findings are published in the Lancet journal, and also determined that individuals with the highest burden of genetic risk had the greatest benefit from statin therapy in terms of reducing their risk. This group experienced three times the risk reduction of those in the low-risk group.

"These findings could play an important role in helping physicians understand which patients will benefit the most from statin therapy," said Dr Jessica L Mega, first author of the research paper and a cardiologist.

Posted by Edward Bartel

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Image Credit: Thinkstock

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