Kidney dopamine linked to hypertension, study finds

21 July 2011

New scientific healthcare research published in the July Journal of Clinical Investigation has found that dopamine produced in the kidneys is related to lifespan, body fluid levels and regulating blood pressure.

Studies have long suggested that dopamine was linked to total body fluid volume but science had so far failed to link the two. However, new research which compared the effects of dopamine produced both inside and outside of the brain showed that the elimination of kidney dopamine increased renin production, which activates the angiotensin II system to increase salt and water re-absorption.

Dr Raymond Harris, chief of the Division of Nephology and Hypertension at Vanderbilt University Medical Centre, said: "Our studies highlight this whole other hormonal system that appears to balance or put the brakes on the renin-angiotensin system."

The research could alter the way in which patients with chronic liver diseases and people with heart problems are treated given the knock-on effects hypertension has on blood pressure.

Posted by Philip Briggs

1 Ming-Zhi Zhang, "Intrarenal dopamine deficiency leads to hypertension and decreased longevity in mice". Journal of Clinical Investigation. Friday July 1st 2011.

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