31 October 2016
A new lab technique has been developed by UK researchers that could aid the development and success of a promising treatment approach for cancer.
The University of Huddersfield have created a means of optimising the treatment approach that involves using polymer beads injected into arteries that feed a tumour to block blood flow and cut off the supply of oxygen and nutrients to the cancerous cells.
They carried out experiments involving in which a buffer - a liquid that mimics blood - was pumped at different rates through the beads, while modifying the quantities of drug they contained, to gain more precise insights into how they work.
By comparing their laboratory observations with in vivo data, they were able to validate a simulation technique for predicting what would happen in a patient's body if the beads and the drug they contain are modified.
By improving the predictability of treatment, the new method could enhance the safety and effectiveness of the bead-based therapy, which is often used to treat liver cancer.
Dr Laura Waters, a University of Huddersfield pharmaceutical science lecturer and researcher, said: "There was no lab mimic that was able to adequately predict how the drug was released from these drug-eluting beads once they were in the body. The article describes a way of doing it in the lab."
Posted by Philip Briggs
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