Two genes with links to breast cancer survival identified

18 August 2016

A new study has identified two genes with potential links to breast cancer survival, a discovery that could aid the development of future diagnostic techniques.

Conducted by the Institute of Cancer Research and Breast Cancer Now, the research assessed data from almost 2,000 women, finding that those whose tumours had a specific pattern of activity in these two genes were three times as likely to die within ten years.

People with high activity in the F12 gene and low activity in the STC2 gene were shown to have a 32 per cent chance of dying within a decade, compared to only a ten per cent mortality risk in those with low F12 activity and high STC2 activity.

More research is now needed to establish how these genes may interfere with the extracellular matrix and help cancer cells grow and spread.

Dr Paul Huang, leader of the protein networks team at the Institute of Cancer Research in London, said: "If the results are confirmed in larger studies, it could give us a new way of assessing women's survival chances in the clinic, and adjusting treatment accordingly."

Posted by Edward Bartel

 


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