New study reveals insights into ovarian cancer drug resistance

16 August 2016

A new UK study has provided potentially useful new insights into the biological mechanisms by which ovarian cancer can develop resistance to common therapies.

Researchers from the University of Dundee have discovered that a gene called ABCB1 - which was previously known to play a role in the development of resistance to the chemotherapy drug paclitaxel in ovarian cancers - also causes resistance to other therapies.

For this study, they administered PARP inhibitor treatments to chemotherapy-resistant ovarian cancer cells grown in the lab, including olaparib and rucaparib. It was shown that the cells used ABCB1 to survive the treatment in the same way they do with paclitaxel.

However, the cells did not show the same immunity to veliparib and AZD2461, two alternative PARP inhibitor treatments.

Dr Gillian Smith, who led the research at the University of Dundee, said: "Our study shows an important resistance mechanism which is common to drugs used routinely in the clinic and to new drugs which are being tested in clinical trials.”

Better understanding of resistance mechanisms helps to support the development of new tests to identify signs of resistance, ensuring patients can receive the most appropriate drug for them. It could also lead to the creation of new, more effective therapies.

Posted by Jeanette Royston

 


Health News is provided by Axonn Media in collaboration with Spire Healthcare. Please note that all copy above is ©Axonn Media and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)