Genetic tumour suppressant identified

 

3 September 2015

Researchers at Boston University School of Medicine have found that a protein complex can work as a tumour suppressant in cases of lymphoma, melanoma, colorectal and breast cancer.

Using bioinformatics, the team discovered that a genetic variation that prevents the APC/C complex from working is often present in the cells of melanomas. From this, they concluded that the gene, which suppresses the Cdh1 protein, is essential for controlling cell division, and thus for preventing some kinds of cancer.

Cdh1 also has an inverse relationship with PAX3, another protein known to play a role in cell reproduction. A lack of Cdh1 prevents excess PAX3 from being broken down, and can lead to the uncontrolled cell division that causes tumours.

Corresponding author Rutao Cui said: "These findings have significant implications to the field of cancer by providing important insights into molecular genetics of melanoma and could lead to the identification of novel preventive strategies and therapeutic targets for melanoma."

Posted by Jeanette Royston

 

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