Parkinson's gene linked to lung cancer

2 February 2015

New findings have linked a gene associated with early-onset Parkinson's disease, with the development of lung cancer.

A team at the Medical College of Wisconsin (MCW), along with peers from the Genetic Epidemiology of Lung Cancer Consortium (GELCC), published their findings in the American Journal of Human Genetics.

Using whole exome sequencing, the researchers were able to identify a link between a mutation in PARK2, which is associated with Parkinson's disease, and familial lung cancer. By studying the protein coding region of the genomes, they were able to see they were from a family with multiple cases of lung cancer.

"While this specific mutation is very rare in the general population, there was a significant association between the PARK2 mutation we studied and the families with multiple cases of lung cancer," said Donghai Xiong, assistant professor of pharmacology and toxicology at MCW and lead author of the paper.

Posted by Jeanette Royston

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