STING plays key role in tumour immunity

21 November 2014

STING - a recently discovered protein complex - plays a significant role in finding tumour cells and encouraging an aggressive anti-tumour response from the body's immune system, new studies have suggested.

Published in the journal Immunity, both pieces of research could have major implications for the growing field of cancer therapies. The University of Chicago-based teams have demonstrated that an activated STING (Stimulator of Interferon Genes) pathway triggers a natural immune response to attack the tumour.

Part of this process activates chemical signals that help the immune system to target tumour cells and generate specific killer T cells. The team also found that high-dose radiation therapy can boost this response.

"We have learned a great deal recently about what we call checkpoints, the stumbling blocks that prevent the immune system from ultimately destroying cancers," said Thomas Gajewski, professor of medicine and pathology at the University of Chicago and senior author of one of the studies.

Professor Gajewski added that a blockade of immune checkpoints, such as with anti-PD-1, can help some patients but many will be unresponsive. Better understanding the role of STING will allow teams to determine how the immune response against tumours can be woken.

Posted by Philip Briggs​

 

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)