Biomarker ‘estimates effectiveness’ of brain cancer treatment

2 July 2014

A newly identified biomarker can predict whether glioblastoma - the most common form of brain cancer - will respond to chemotherapy, according to research from the University of California, San Diego School of Medicine.

Dr Clark C Chen, the study’s lead investigator, said: "Every patient diagnosed with glioblastoma is treated with a chemotherapy called temozolomide. About 15 per cent of these patients derive long-lasting benefit.

“We need to identify which patients benefit from temozolomide and which another type of treatment. All therapies involve risk and the possibility of side-effects. Patients should not undergo therapies if there's no likelihood of benefit."

To identify the patients are most likely to respond to the treatment, researchers studied microRNAs, which control the expression of a protein called methyl-guanine-methyl-transferase (MGMT). 

Tumours containing high levels of the protein often display a poor response to temozolomide therapy.

The research team tested every microRNA in the human genome to find those that suppressed MGMT expression, as they theorised that high-levels of the molecules would predict an improved response to chemotherapy.

Dr Chen claims his team’s theory was correct and validation of the results should lead to diagnostic tools to identify which glioblastoma patients will benefit the most from temozolomide therapy.

Posted by Philip Briggs


Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)