Cancer-related DNA faults 'more common in people with type-2 diabetes'

15 July 2013

People with type-2 diabetes are more likely to have a particular form of cancer-related genetic abnormality than the general population, a study has found.

Researchers at Imperial College London looked for gene faults called 'clonal mosaic events' (CMEs) in blood samples from almost 7,500 people, including 2,208 with type-2 diabetes.

These faults have previously been shown to be associated with a ten-fold increased risk of blood cancers, which are known to be particularly common among people with type-2 diabetes.

They discovered that these faults were four times more common among people with type-2 diabetes.

Lead researcher Professor Philippe Froguel said: "Type-2 diabetes is a disease that accelerates ageing, so we wondered if it would make people more likely to have these genetic defects that are associated with ageing.

"This finding may partly explain why people with type-2 diabetes are more likely to get blood cancers."

Professor Froguel added that the finding - which is published in the journal Nature Genetics - could have important implications as it could enable doctors to identify type-2 diabetes patients with the highest risk of these cancers.

Posted by Edward Bartel

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