Nanoparticle 'improves children's cancer treatment'

21 November 2012

Scientists have developed a nanoparticle that could improve chemotherapy for childhood cancer.

Research published in the journal Chemical Communications, found that the nanoparticle could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

The non-toxic particle is able to deliver and release nitric oxide (NO) to specific cancer cells in the body.

It is a particularly significant finding given that neuroblastoma treatment often leaves survivors with ongoing problems due to the high doses of chemotherapy drugs that are required for treatment.

Co-author Dr Cyrille Boyer, from the University of New South Wales, said: "When we injected the chemo drug into the neuroblastoma cells that had been pre-treated with our new nitric oxide nanoparticle we needed only one-fifth of the dose.

"By increasing the effectiveness of these chemotherapy drugs by a factor of five, we could significantly decrease the detrimental side-effects to healthy cells and surrounding tissue."

Posted by Philip Briggs

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