Drugs 'could be used to target lung cancer'

10 September 2012

A large-scale lung cancer study has indicated that more targeted therapies could be used in an effort to prevent mortality.

The study, which was published in the journal Nature, found that almost 75 per cent of patients with squamous cell carcinoma of the lung have mutations that can be targeted through existing drugs, which are available commercially or for clinical trials.

While current treatment for squamous cell lung cancers includes chemotherapy and radiation, there are no drugs which are specifically designed to target this particular type of lung cancer.

For the research, scientists examined the tumours and normal tissue of 178 patients with the cancer, and found recurring mutations common to many patients in 18 genes.

Furthermore, almost all of the tumours exhibited mutations in a gene called TP53, which is known for its role in repairing damaged DNA.

Richard K Wilson, PhD, director of The Genome Institute at Washington University, explained: "We clearly see mutations in lung cancer that we see in other human cancers.

"This reinforces something that we've been seeing in a lot of our cancer genomics work. It's really less about what type of tissue the tumor arises in – lung, breast, skin, prostate – and more about what genes and pathways are affected."

Posted by Edward Bartel


Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)