New drug 'could target tumour-inducing stem cells'

8 December 2011

An experimental drug has shown promising results in targeting cancer stem cells and has been deemed a "novel approach to treatment research".

Researchers at Loyola University Medical Center in Chicago found a therapeutic approach to targeting cancer stem cells worked in clinical trials and that this could help to kill those stem cells that are often resistant to existing methods of treatment.

Known as a 'notch inhibitor', the drug appears to block the process whereby mature cancer stem cells develop into new tumour cells by turning off key genes.

Leader of the study Kathy Albain said: "Our results suggest a potential role that notch inhibitors could play in optimising existing therapies and in overcoming resistance to cancer drugs."

She added that results of the clinical trial showed promising results and will form a foundation for further research and development.

Women with early-stage breast cancer were tested as part of the clinical trial and results showed that the tested drug turned off the key genes that in effect would have kept the tumour stem cells resistant to conventional drugs.

Breast cancer is most commonly treated through chemotherapy, radiotherapy and hormonal therapy.

Posted by Jeanette Royston

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.
 

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)