Xiapex injection for Dupytren's contracture

A new injection that offers sufferers of Dupuytren's contracture a non-operative treatment plan to treat the disease is now available here at Spire Washington Hospital.

We expect to see immediate results and achieve an 80%-100%
straight away
Mr Jeff Auyeung, Consultant Orthopaedic Surgeon

Dupuytren's disease is a condition that affects palms of the hand, causing the fibrous tissues under the skin to thicken and contract and fingers to bend inwards. It traditionally affects middle aged to elderly males but it can affect others too. Sufferers can’t straighten their hand, put it flat on the table, put their gloves on or get their hand into their pocket – lots of things about daily life are difficult. It can be painful in the early stages due to changes in the fibrous tissue collagen composition but the pain tends to subside after that.

What to expect

The Xiapex is injected into the fibrous cords (the thickened bands of tissue) just under the skin that are causing the problem. Patients have to stay for half an hour. The injection takes about 24 hours to work as the enzymes break down the abnormal fibrous tissue and patients are then asked to come back the next day for 'manipulation' under local anaesthetic. The bent finger is straightened out by applying pressure and performing an extension procedure. At the end of this patients are given a hand splint to wear overnight to maintain the correction for 4 weeks before they come back for a final follow up.

We expect to see immediate results with the injection and achieve an 80% to 100% improvement straight away. If the consultant is not satisfied with the progress made it is possible to re-inject and re-manipulate up to three times.  


The cost per Xiapex injection is £1500, this does not include the consultation fee. Research literature indicates patients normally require 1.7 injections of the the two enzymes to break down the thickened bands of tissue. 

Who performs the procedure?

Here at Spire Washington Hospital we have two orthopaedic surgeons who perform the Xiapex injection for Dupytren's contracture, Mr Jeff Auyueng and Mr Malcolm Jones, who both hold weekly clinics here at the hospital.

Further treatment

Dupytren's contracture is a genetic condition so the problem can recur at any time, whether treated with the Xiapex injection or surgery. In the event that the condition returns further injections can be carried out to improve the area.

More information from Spire Washington Hospital

We're here to help, so if you require any further information, have a question or would like to make an appointment to see one of our consultants, please contact us on 0191 418 8687 or email us at info@spirewashington.com.

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