New study casts doubt on concept of 'healthy obesity'

19 August 2016

New research has indicated that previous assumptions that it is possible to be obese while remaining otherwise healthy may not be accurate.

The Karolinska Institutet study provided evidence that white fat tissue samples from obese individuals classified as either metabolically healthy or unhealthy showed nearly identical abnormal changes in gene expression in response to insulin stimulation.

Recent estimates suggest that up to 30 per cent of obese individuals are metabolically healthy and therefore may need less vigorous interventions to prevent obesity-related complications. High sensitivity to insulin which promotes the uptake of blood glucose into cells to be used for energy, is considered a hallmark of metabolically healthy obesity.

However, this new research casts fresh doubt on whether any such thing exists, indicating that insulin-sensitive obese people may not be as metabolically healthy as previously believed.

Mikael Ryden of the Karolinska Institutet said: "The findings suggest that vigorous health interventions may be necessary for all obese individuals, even those previously considered to be metabolically healthy."

Researchers will now examine the outcomes of these patients following bariatric surgery to determine whether weight loss normalises their responses to insulin.

Posted by Jeanette Royston

 


Health News is provided by Axonn Media in collaboration with Spire Healthcare. Please note that all copy above is ©Axonn Media and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Weight loss surgery

© Spire Healthcare Group plc (2016)