Scientists discover mechanism to reduce obesity

7 December 2012

Scientists have uncovered a mechanism that could cut levels of obesity, according to a new paper.

A team led by the Virginia Commonwealth University Massey Cancer Center managed to successfully reverse obesity in mice by manipulating production of an enzyme known as tyrosine-protein kinase-2 (Tyk2).

It was found that Tyk2 helps to regulate obesity in mice and humans through differentiation of a type of fat tissue known as brown adipose tissue (BAT), according to the study, which was published in the journal Cell Metabolism.

Researchers were able to reverse obesity in mice that do not express Tyk2 by instead expressing a protein that activates transcription-3 (Stat3).

Stat3 was seen to form a complex with a protein known as PR domain containing 16 (PRDM16), restoring the development of BAT and decreasing obesity.

Study leader Andrew Larner commented: “We plan to further investigate the actions of Tyk2 and Stat3 in order to better understand the mechanisms involved in the development of brown adipose tissue.

"We’re hopeful this research will help lead to new targets to treat a variety of obesity-related diseases such as cancer, cardiovascular disease and diabetes.”

Posted by Edward Bartel


Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Weight loss surgery

© Spire Healthcare Group plc (2016)