Single molecule 'can trigger stem cells to aid bone regrowth'

1 September 2016

Bone recovery processes in the human body could potentially be kickstarted with the use of a single molecule, according to a new study.

Research from the University of California - San Diego has indicated that adenosine, a naturally occurring molecule in the body, can represent an easy way of coaxing human pluripotent stem cells to regenerate bone tissue.

In this study, human pluripotent stem cells were turned into functional bone-building osteoblasts by adding adenosine to their growth medium, with the resulting osteoblasts showing the ability to generate bone tissues with blood vessels, just as in the body.

When transplanted into mice with bone defects, the osteoblasts formed new bone tissues in vivo without any signs of teratoma tumour formation.

Senior study author Shyni Varghese, a bioengineering professor at the University of California - San Diego, said: "One of the broader goals of our research is to make regenerative treatments more accessible and clinically relevant by developing easy, efficient and cost-effective ways to engineer human cells and tissues."

Posted by Jeanette Royston

 


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