10 August 2016
Research into how the body suppresses inflammation at night could aid the future development of new arthritis therapies.
A team from the University of Manchester looked at cells from the joint tissue of healthy mice and humans called fibroblast-like synoviocytes, which are known to play a key role in causing inflammatory arthritis.
They identified a protein called cryptochrome created by the body's biological clock that actively repressed inflammatory pathways within affected limbs during the night. Drugs designed to activate the cryptochrome protein were subsequently found to deliver protection against inflammation.
Not only does this research help to explain why many people with arthritis experience stiffness in the morning, but it also identifies a protein that could prove a useful new target in the future treatment of arthritis and other inflammatory conditions.
Dr Julie Gibbs, Arthritis Research UK career development fellow at the Centre for Endocrinology and Diabetes at the Institute of Human Development at the University of Manchester, said: "By understanding how the biological clock regulates inflammation, we can begin to develop new treatments, which might exploit this knowledge."
Posted by Edward Bartel
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