New study shows how body suppresses inflammation at night

10 August 2016

Research into how the body suppresses inflammation at night could aid the future development of new arthritis therapies.

A team from the University of Manchester looked at cells from the joint tissue of healthy mice and humans called fibroblast-like synoviocytes, which are known to play a key role in causing inflammatory arthritis.

They identified a protein called cryptochrome created by the body's biological clock that actively repressed inflammatory pathways within affected limbs during the night. Drugs designed to activate the cryptochrome protein were subsequently found to deliver protection against inflammation.

Not only does this research help to explain why many people with arthritis experience stiffness in the morning, but it also identifies a protein that could prove a useful new target in the future treatment of arthritis and other inflammatory conditions.

Dr Julie Gibbs, Arthritis Research UK career development fellow at the Centre for Endocrinology and Diabetes at the Institute of Human Development at the University of Manchester, said: "By understanding how the biological clock regulates inflammation, we can begin to develop new treatments, which might exploit this knowledge."

Posted by Edward Bartel


Health News is provided by Axonn Media in collaboration with Spire Healthcare. Please note that all copy above is ©Axonn Media and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:


Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.


Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...


Orthopaedic surgery

© Spire Healthcare Group plc (2016)