New way to extract bone-making cells

6 October 2014

New research, published in the journal Stem Cell Research & Therapy, has revealed a novel method to draw bone-producing cells from fat.

Human fat houses a variety of cells with the potential to develop into bone, cartilage, or more fat if properly prompted. This makes this adipose tissue, in theory, an available pool for regenerative therapies such as bone healing, if scientists are able to get enough of those cells and encourage them to produce bone.

A team at Brown University developed a fluorescent tag that could find and identify cells expressing a gene called ALPL, which suggests they have the potential to make bone. If this tag identifies the RNA produced when the gene is expressed, it latches on and glows. 

A device that can detect the fluorescing light then separates out the ALPL-expressing cells. This method, according to the team, was able to produce more than twice the yield of potential bone-makers (nine per cent) compared to their best outcome of another method, which generated just four per cent.

Posted by Jeanette Royston​

 

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Ophthalmology

© Spire Healthcare Group plc (2016)