Cell repair failures identified in diabetes complications

5 August 2015

Complications in patients with type one diabetes have been linked to specific cell repair failures, allowing scientists to explore more effective treatment and diagnosis options before symptoms become dangerous.

Senior author Rohit Kulkarni said: "Even with very good glycemic control, people with type 1 diabetes can still develop complications that impact their ability to work and quality of life.”

Complications from type one diabetes are a leading cause of death in sufferers, and can affect the eyes, kidneys, nerves, heart and blood vessels.

The team from the Joslin Diabetes Center in Boston used induced pluripotent stem (iPS) cells to model the disease, and discovered that there were higher levels of the protein miR200 in cells from participants who had severe complications.

This substance is known to play an important role in cell repair. When the researchers reduced the level of miR200 in the cells, repair functions were restored. It is hoped that in the future, miR200 levels could be used to diagnose complications before serious damage occurs.

Posted by Philip Briggs


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