Molecule that slows diabetic wound healing identified

26 January 2015

One of the most unpleasant long-term symptoms of diabetes is impaired wound healing. Overall, 15 per cent of diabetics will suffer a non-healing wound over their lifetime, which often becomes a cause of amputation after ulceration takes place.

However, researchers at the University of Pennsylvania School of Dental Medicine have found that a protein called Foxo1 may be responsible for the lack of healing. It had earlier been thought that this protein might have been beneficial to the healing process, but the researchers found that the opposite was the case for diabetics.

Laboratory tests showed that diabetics with abnormally low levels of Foxo1 healed more quickly than others: the reverse of the results for those without diabetes. On a molecular level, cell movement and propagation was seen to be impaired in a high-sugar environment, offering a possible explanation for the disparity.
"In terms of a wound-healing response, it looks like Foxo1 might be one of the central regulators that are affected by the diabetic condition," said lead researcher Dana T. Graves.

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

Posted by ​Phillip Briggs 

 

Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.

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