New therapeutic target for diabetic wound healing

5 September 2014

New research published in the Cell Press journal Chemistry & Biology has determined a family of chemical mediators that could prove to be an effective target for diabetic treatment.

The group, led by Dr Song Hong's group at the LSU Health New Orleans, identified a novel family of chemical mediators that restore the repairing ability of certain white blood cells - macrophages - that are impaired by diabetes. This restores their ability to heal wounds and calm inflammation.

These white blood cells in the immune system help protect the body from infection or other foreign invaders. Evidence has also suggested that, when combined with platelets, they play an important role in the healing process.

Diabetes stops the macrophages' ability to repair and regenerate cells and organs after an injury.

The team found that these white blood cells or leukocytes in the immune system and platelets produce a group of molecules - called Maresin-Ls. These promote wound healing but the research also determined which enzymes are needed in the cells to produce these molecules. 

They demonstrated that treatment by these novel molecules restores reparative functions to diabetic macrophages, enabling the cellular processes known to be critical to wound healing and suppressing those causing chronic inflammation associated with non-healing diabetic wounds.

Posted by Philip Briggs​

 

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