Stem cells used to reprogram adult cells

17 September 2014

New research has developed a method that is highly effective to manipulate adult cells into becoming a cocktail of quality pluripotent stem cells.

The work at the Hebrew University of Jerusalem is part of an expanding faction of medical research that aims to replace lost or damaged areas through cellular transplantation. As stem cells are derived from human embryos and can trigger ethical concerns, a new solution is to reprogram adult cells to return to an embryo-like state.

This then results in induced pluripotent stem cells (iPSCs), which can be used to replace lost, damaged or diseased cells. However, there have been concerns about the stability of these iPSCs as they can present genetic abnormalities.

However, researchers from the Hebrew University of Jerusalem have developed a new cocktail of reprogramming factors that produces high-quality iPSCs. 

Dr Yosef Buganim and research scientist Styliani Markoulaki used bioinformatic analysis to design a new cocktail of reprogramming factors, which revealed that the interaction between reprogramming factors plays a crucial role in determining the quantity and quality of iPSCs.

This discovery could have a significant clinical impact on future surgeries, as well as helping to fight disease.

Posted by Edward Bartel

 

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