Women with PCOS 'see greater fertilisation success with frozen embryos'

12 August 2016

Women with polycystic ovary syndrome (PCOS) who are trying to conceive will generally see more success using frozen embryos compared to fresh ones.

This is according to a new study from Penn State College of Medicine, conducted in collaboration with Chinese researchers, which indicated that frozen embryos could improve the rate of live births and lower the rate of pregnancy complications in women with PCOS.

To assess this trend, 1,508 infertile women with PCOS were randomised to receive either fresh or frozen embryos during their first in vitro fertilisation cycle. Frozen embryos were shown to lower the rate of ovarian hyperstimulation syndrome from 7.1 to 1.3 per cent compared to using fresh embryos.

Frozen embryos also had a higher frequency of live births - due to fewer pregnancy losses - and generally higher birth weights.

It was suggested this could be because frozen embryo transfer allows the ovary to recover from stimulation during in vitro fertilisation, while also allowing time for the exposed endometrial lining to shed.

Dr Richard Legro, professor of obstetrics and gynaecology and public health sciences at Penn State College of Medicine, said: "By electing to freeze all the embryos, you create a healthy environment for the best embryos, as opposed to putting them back in a disturbed environment."

Posted by Philip Briggs


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