Location of colon cancer 'affects patient outcomes'

2 November 2016

The side of the body on which colon cancer grows can have an effect on the eventual outcome of the disease's development, according to a new study.

Published in JAMA Oncology, the research reviewed 66 studies involving more than 1.4 million patients, with a median follow-up of 65 months, to determine the differences between right and left colon cancer.

It was shown that left-sided primary tumour location was associated with a nearly 20 per cent lower risk of death, a difference that was independent of other relevant clinical factors such as tumour stage and receipt of chemotherapy.

Previous research has indicated that localisation of colon cancer on either the right or left side can influence prognosis due to differing biological features, including genetic variations, and this study adds credence to that idea.

The study concluded: "Primary tumour locations should be carefully considered when deciding treatment intensity in metastatic and locoregional settings, and should represent an important stratification factor for future adjuvant studies."

Posted by Jeanette Royston


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