Blocking fat cell signals 'could aid fight against prostate cancer'

14 January 2016

A new study has offered new evidence of the link between obesity and prostate cancer, while shedding light on a possible means of combating the disease.

The University of Toulouse study, published in the journal Nature Communications, looked at lab mice and determined that cells surrounding the prostate release a protein called CCL7, which sticks to a molecule on the surface of prostate cancer cells called CCR3, a process that helps the cancerous cells to move and spread.

A subsequent examination of tissue samples from men with prostate cancer also showed that higher levels of the CCR3 molecule were more common in the most aggressive forms of the disease.

As such, the researchers believe that blocking these fat cell signals may help prevent prostate cancer from spreading, aiding the development of targeted treatments.

The research also supports the growing body of evidence showing how being obese can influence how aggressive prostate cancer is.

Dr Aine McCarthy, science information officer at Cancer Research UK, said: "This research serves as a reminder of the link between obesity and cancer, and that we need urgent action to combat the obesity epidemic."

Posted by Philip Briggs

 


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