Four-gene signature could predict cancer, study shows

11 October 2011

A four-gene signature could accurately predict which patients are at higher risk of contracting head and neck cancers, research suggests.

Oral Squamous Cell Carcinoma (OSCC) is responsible for nearly a quarter of all head and neck cancers, one of the leading causes of cancer death.

Researchers at Ontario Cancer Institute at University Health Network Toronto found that the ability to predict OSCC recurrence could lead to a lower risk of deaths from such cancers.

Published in BioMed Central's open-access journal BMC Cancer, the study looked at previous research and conducted further analysis of gene structures to find the signature which could detect probabilities for head and neck cancers.

The research was led by led by Dr Suzanne Kamel-Reid and Dr Igor Jurisica.

One of the researchers commented: "Patients at higher risk of recurrence could potentially benefit from closer disease monitoring and/or adjuvant post-operative radiation treatment, even in the absence of other clinical and histopathological indicators."

Oral cancers include tongue and oropharyngeal types of the disease.

Posted by Jeanette Royston

Kamel-Reid, S, et al., "A gene signature in histologically normal surgical margins is predictive of oral carcinoma recurrence", BMC Cancer, October 2011.


Health News is provided by Adfero in collaboration with Spire Healthcare. Please note that all copy above is ©Adfero Ltd. and does not reflect views or opinions of Spire Healthcare unless explicitly stated. Additional comments on the page from individual Spire consultants do not necessarily reflect the views or opinions of other consultants or Spire Healthcare.
 

Find a treatment, test or scan available at:

or

Find a consultant

Use one or more of the options below to search for a consultant and link through to view their Spire profile.

or

Let us help you

fill out this form and we will get back to you:

Please select a hospital

We can call you

Please enter your details below and we will call you back.

What is the aim of your enquiry?

Please select a hospital

If we are unable to reach you by phone, please include your email address so that we can get in touch...

Categories

Cancer

© Spire Healthcare Group plc (2016)