20 September 2011
The development of a new type of nanoparticle could show increased potential of using chemotherapy to treat cancer patients.
A study at the University of North Carolina led by Wenbin Lin showed that a new type of nanoparticle can deliver larger amounts of a drug and will not leak the medication as the particle circulates through the blood stream on its way to the target cancerous cells.
In tests, Mr Lin and his colleagues tested the nanoparticle's ability to deliver the chemotherapy drug oxaliplatin to tumours in the colon and pancreas, cancers that are renowned as difficult to treat. The team found that the nanoparticle has two to three times greater therapeutic efficacy over oxaliplatin.
Mr Lin said: "The polysilsesquioxane particle we have developed carries extremely high loadings of oxaliplatin-based chemotherapeutics. The particles are stable under normal physiological conditions, but can be readily reduced to release the platin cargoes."
He added that the nanoparticle is able to release the drug in a controlled fashion.
Oxaliplatin was discovered in 1976 at Nagoya City University by Professor Yoshinori Kidani.
Posted by Jeanette Royston
Wenbin, Lin et al., Angewandte Chemie September 14th 2011.
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